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Together with the lidocaine-prilocaine 1:1 mixture, the poloxamers form a low-viscosity fluid system at room temperature and an elastic gel in the periodontal pocket. However, in effective doses, lidocaine and prilocaine has not been shown to cause different side effects or problems in children older than 1 year of age than it does in adults. The following information includes only the average doses of lidocaine and prilocaine. Very young children (less than 1 year of age) may be especially sensitive to the effects of lidocaine and prilocaine. When administered intravenously, the mean volume of distribution (for 60-kg person) at steady state for lidocaine and prilocaine were 90 L and 156 L, respectively. The prilocaine metabolite o-toluidine and the hydroxylated metabolites of o-toluidine are excreted mainly in the urine.

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